The multivariate analysis confirmed the variables “age ≥ 65 years” (p = 0.036, OR 1.46, 95% CI 1.03–2.1), “infratentorial location of BM” (p = 0.023, OR 1.53, 95% CI 1.1–2.2), “preoperative CRP > 10 mg/L” (p = 0.034, OR 1.49, 95% CI 1.03–2.2), “perioperative RBC transfusion” (p = 0.001, OR 2.58, 95% CI 1.4–4.6), “postoperative PMV > 48 h” (p = 0.042, OR 2.79, 95% CI 1.04–7.5) and “occurrence of PAE” (p = 0.001, OR 2.98, 95% CI 1.6–5.7) as significant and independent predictors of a poor OS after a surgical treatment of BM seeded by NSCLC (Figure 4). This evidence concerns the gene CRP and pulmonary artery enlargement.