The significant effect of the group, time considered separately, as well as the interaction between the group and the time simultaneously were recorded in GH (p = 0.034, p < 0.001, p = 0.004, respectively), IGF-1 (p = 0.027, p < 0.001, p = 0.012, respectively) concentrations, and adenoma MD (p = 0.042, p < 0.001, p < 0.001, respectively) (Figure 3A–F). This evidence concerns the gene GH1 and adenoma.