Our results show that the V433M SNP in the CYP4F2 gene, which is responsible for the synthesis of 20-HETE, a major mediator in hyperglycemia-induced renal cell damage, is associated with a decreased risk of DKD and low eGFR values in these patients, which suggests this could be a useful marker in the diagnosis and follow-up of DKD patients. The gene discussed is CYP4F2; the disease is diabetic kidney disease.