Interestingly, prior cardiovascular risk factors (present in 7–55% of our study participants), cardiovascular diseases (present in 5–21%) and prior medication therapy, including renin-angiotensin-aldosterone-system-inhibitors, betablockers, diuretics, statins and antidiabetic medication (present in 19–37%) were not major predictors for a manifest cardiovascular event in our model but have been subject of discussion in the current literature [4,24]. Here, REN is linked to cardiovascular disorder.