TNF and synovial sarcoma: Earlier, in vitro studies using a human salivary adenocarcinoma cell line have shown that proinflammatory cytokines TNF-α and IFN-γ, which are highly expressed in SS salivary glands, are capable of inhibiting cell growth [47,48] as well as causing the downregulation of IGF1R, suppressing the promoter of the gene [49].