Bi-allelic MYO5B mutations, excluding bi-allelic nonsense and/or frameshift mutations that give rise to premature termination codons and/or loss of the RAB11A binding site in the encoded myosin Vb protein, were also found in 14 patients who displayed no or episodal intestinal symptoms and were diagnosed with progressive familial intrahepatic cholestasis (PFIC)-type 6 [19,20]. The gene discussed is RAB11A; the disease is progressive familial intrahepatic cholestasis.