As demonstrated, molecules secreted by CAFs, i.e., TGFβ1, EGF, HGF, and FGF-2, potentiate the migration and invasion of endometrial cancer cells (RL-952) when administered exogenously, thus inducing lung metastasis in vivo in mouse subcutaneous xenograft assay [265]. Here, FGF2 is linked to endometrial cancer.