The HNPCC patients display TGFBR2 mutations more frequently in colorectal than endometrial cancers (88% vs. 25%), and the main difference between these tumor types is PTEN instability, which seems to be characteristic for uterine tumorigenesis in this pathology [231] (Table 1). This evidence concerns the gene TGFBR2 and hereditary nonpolyposis colon cancer.