TGFB1 and endometrial carcinoma: The results obtained in discussed mouse models support that the loss of growth inhibitory function of TGFβ signaling contribute to endometrial carcinogenesis presented by Parekh et al. In that study, the primary cultures of endometrial epithelial cells derived from normal proliferative endometrium underwent dose-dependent and maximal growth inhibition up to 55% ± 5.3% when treated with 10 pM TGFβ1, whereas endometrial epithelial cells derived from endometrial carcinomas stayed unresponsive to TGFβ1 isoform [209].