It is noteworthy that ACE2 and TMPRSS2 are expressed at high levels on tumor and normal colorectal epithelial tissues and that patients with colorectal cancer and COVID-19 are more likely to have lymphopenia, higher respiratory rate, and high hypersensitive C-reactive protein levels than matched patients with COVID-19 but without cancer [53,54]. Here, ACE2 is linked to COVID-19.