MUC16 and idiopathic pulmonary fibrosis: We noted negative correlations between circulating SP-D levels and CA-125 levels at each study timepoint during anti-fibrotic therapy of IPF subjects: at baseline r = −0.52, p < 0.01, at 6 months r = −0.53, p < 0.01, at 12 months r = −0.45, p < 0.05, at 18 months r = −0.48, p < 0.05 and at 24 months r = −0.49, p < 0.01.