In the present study, we directly compared the clinical usefulness of seven circulating biomarkers, including KL-6, SP-D, MMP-7, CA19-9, CA-125, CCL18, and periostin, serially measured in a cohort of patients with IPF receiving anti-fibrotic therapy over 24 months. This evidence concerns the gene MUC16 and idiopathic pulmonary fibrosis.