The comparison of patients without lymph nodes metastases (N0) and the patients with metastases in any group of lymph nodes (N1) revealed that TSP-1 serum levels were decreased in lung cancer patients with lymph nodes involvement (10,000.13 ± 9021.41 ng/mL vs. 18,497.75 ± 12,548.25 ng/mL; p = 0.01), (Figure 3). This evidence concerns the gene THBS1 and lung cancer.