Taking into account the combined influence of BMP-4 and TSP-1 on cancer cells [22,23] we aimed to investigate the serum levels of TSP-1 and BMP-4 together with SNP of gene coding for BMP-4 (rs1957860) in lung cancer patients in relation to histological type, lymph nodes involvement and the presence of remote metastasis. The gene discussed is THBS1; the disease is cancer.