In addition, TSP-1 serum levels were lower in patients with advanced lung cancer stages III-IV than in patients with early stages I-II (9282.07 ± 4900.78 ng/mL vs. 16,933.60 ± 6299.02 ng/mL; p = 0.03), (Table 1, Figure 2). Here, THBS1 is linked to lung cancer.