Nuclear factor-κB (NF-κB), which mediates the increase in the secretion by microglia of such cytokines as IL-1β and IL-18 and is activated by IL-1β, TNF-α, PAMP, adrenal cortex hormones and adrenaline, may play an important role in the potential pathological feedback loop associated with disturbances in the cytokine network in schizophrenia [119]. This evidence concerns the gene IL18 and schizophrenia.