It is also important to note that there may be sex differences in arrhythmogenic potentials secondary to underlying conditions, such as catecholaminergic polymorphic ventricular tachycardia (CPVT) associated with cardiac ryanodine receptor 2 (RyR2) mutations and other cardiac pathologies [116,117,118,119,120,121,122,123,124,125]. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.