Similarly, Chen et al. reported that HIT worsened hypertension and intensified adverse remodeling of L-type voltage-gated Ca2+ (Cav1.2) channels (upregulation of Cav1.2 channels is a hallmark feature of hypertension) in mesenteric arteries of male SHR; females were not studied [182]. Here, CACNA1C is linked to hypertensive disorder.