IgE-mediated food allergy is a common cause of enteric disease, and, in the study conducted by Strait et al. concerning IgE-mediated systemic anaphylaxis induced by ingested allergens, it has been found that both serum antigen-specific IgG and IgA antibodies can protect against severe IgE-mediated allergic reaction [130]. The gene discussed is IGHE; the disease is food allergy.