CD40LG and common variable immunodeficiency: Important factors in establishing the diagnosis of IgA deficiency are family background and other laboratory parameters, which are relevant in order to differentiate sIgAD from CVID (lowered IgA/IgG and sometimes IgM levels), secondary hypogammaglobulinemia (moderately low levels of IgA), single-gene primary immunodeficiencies, hypoglobulinemia due to the protein loss as the result of enteropathy or nephrotic syndrome and malignancies such as thymoma, myeloma, and chronic lymphocytic leukemia [64,65].