Furthermore, TAL1 forms the central node of the core regulatory circuit to coordinately regulate downstream target genes with several hematopoietic transcription factors including GATA3, RUNX1, MYB, and the ETS family genes, which is active in normal hematopoietic stem cell (HSC) and progenitor cells [152,153], and RUNX1 inhibition is reported to impair the growth of T-ALL but not normal hematopoietic cells [154]. Here, RUNX1 is linked to acute lymphoblastic leukemia.