If genomic approaches are not available, a more targeted screening approach using routine diagnostics, including flow cytometry (especially for CRLF2, for which positivity on flow cytometry is strongly correlated with rearrangement) and FISH for the most common kinase targets of rearrangement, is still effective for swift identification of Ph-like ALL [104]. The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.