ZNF384-, or less commonly, ZNF362-rearranged acute leukemia is a biologically and clinically distinct leukemic subtype present in ~6% of childhood, 7.3% of adult, and 15% of AYA B-ALL, and in 48% of B/myeloid mixed phenotype acute leukemia (MPAL) [7,13,91,92,93]. This evidence concerns the gene ZNF384 and acute lymphoblastic leukemia.