Several are associated with ALL subtype, for example, variants in GATA3 have been associated with an increased risk of Philadelphia- like (Ph-like) ALL in patients of Hispanic ancestry [17], variants in TP63 and PTPRJ with ETV6-RUNX1 ALL [18] and in ERG with TCF3-PBX1 ALL and African American ancestry [19,20]. The gene discussed is GATA3; the disease is acute lymphoblastic leukemia.