Low hypodiploidy instead is uncommon in children (~1%) but present in >10% of adults, and is characterized by deletion of IKZF2, RB1, CDKN2A/CDKN2B and near-universal mutations of TP53 mutations, which are inherited in approximately half of cases and indicate that low hypodiploid ALL is a manifestation of Li-Fraumeni syndrome [28]. This evidence concerns the gene TP53 and acute lymphoblastic leukemia.