ETV6-RUNX1-like ALL is characterized by a gene expression profile and immunophenotype (CD27 positive, CD44 low to negative) similar to ETV6-RUNX1 ALL, but lacking the ETV6-RUNX1 fusion [122] and favorable prognosis [7,13,75,122,123]. Here, RUNX1 is linked to acute lymphoblastic leukemia.