Among those the missense p.Asn159Tyr mutation defines a subtype (<1% of B-ALL) with a distinct gene expression profile characterized by upregulation of genes with roles in oncogenesis (the IKZF1-interacting gene YAP1), chromatin remodeling (SALL1), and signaling (ARHGEF28) that are not deregulated in other subgroups of IKZF1-altered ALL [7,74]. Here, IKZF1 is linked to precursor B-cell acute lymphoblastic leukemia.