In the first category, single platform WTS provides near comprehensive characterization of clinically relevant alterations in ALL, particularly B-ALL: gene expression-based profiling to identify subgroups and phenocopies; fusion transcripts; and interrogation of specific sequence mutations (e.g., JAKs, PAX5 and IKZF1) [7,193]. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.