Mutations of genes encoding mediators of Ras signaling (KRAS, NRAS, FLT3, PTPN11) and regulators of chromatin state (e.g., the histone 3 lysine 18 and 27 acetylase and transcriptional coregulator CREBBP, and the H3K36 methylase WHSC1) are frequent concomitant genetic events in high hyperdiploid ALL [23]. This evidence concerns the gene FLT3 and acute lymphoblastic leukemia.