Similar reservations to WTS apply regarding the limited ability of these platforms to detect intergenic rearrangements in ALL; moreover, these platforms either have limited (Foundation) or no (Archer) capability to detect DNA copy number alterations, particularly those that are single copy, and may have difficulty resolving complex rearrangements (e.g., truncating rearrangements of EPOR in Ph-like ALL) [115]. This evidence concerns the gene EPOR and acute lymphoblastic leukemia.