Results of a large, retrospective analysis including data from 756 pediatric patients with KMT2A-rearranged AML, showed that the t(4;11)(q21;q23.3)/KMT2A-MLLT2, t(6;11)(q27;q23)/KMT2A-MLLT4, t(10;11)(p12;q23)/KMT2A-AF10 and t(10;11)(p11.2;q23)/KMT2A-ABI1 were associated with a dismal outcome [60]. Here, KMT2A is linked to acute myeloid leukemia.