NOD2 and Cowden disease: The study of Lesage et al. (2002) indicated that 49% of the patients with familial CD had one (32%) or two (17%) mutant NOD2 alleles; in their research, detected mutations in the majority were localized in the distal part of the gene, and the three common mutations (R702W, G908R, and 1007fs) accounted for 81% of identified alterations [16].