IL1B and periodontitis: Nonetheless, the results of the IL-1 (+3954) SNP’s association with chronic periodontitis and coronary heart disease have been contradicting with those of some previous studies, thereby no evidence of a link between the IL-1 +3954 SNP and GP [9] has been elicited, whereas others have found a clear link between the CT genotype and disease severity in various populations [10,11].