It is well known that the activation of the degradation of IκB-α, STAT-1, and MAPK in keratinocytes are associated with AD, and keratinocytes stimulated with TNF-α/IFN-γ are widely used for verification of the in vitro efficacy of anti-atopic dermatitis [19,20]. The gene discussed is NFKBIA; the disease is Alzheimer disease.