For instance, admittedly, inactivating mutations or alterations of p53 can be seen as a key primary event for the transformation of epithelial gastric cells, but it is not the same for glioblastoma or colon cancer, in which different tumor suppressor genes are primarily mutated (e.g., APC for colon cancer) [2]. The gene discussed is TP53; the disease is malignant colon neoplasm.