Previous studies have shown that CAPE could regulate the p38 signaling pathway to attenuate the neuroinflammatory response in the hippocampus on LPS-induced microglial activation [9], and it could also protect neurons against glutamate-induced excitotoxicity and extend the survival of amyotrophic lateral sclerosis (ALS) mice by inhibiting phosphorylation of p38 [33,34]. The gene discussed is MAPK14; the disease is amyotrophic lateral sclerosis.