Taking into consideration that PKC and NF-κB inhibitors hindered the adherence of B-ALL cells to MSC, but only HKPS or ENZA increased the susceptibility to DEXA and VNC, we studied if these inhibitors were capable to modify the cell binding-associated signaling described above (Figure 2A). This evidence concerns the gene PRRT2 and precursor B-cell acute lymphoblastic leukemia.