VEGFA and neoplasm: The following pathways include inhibition of the extracellular matrix of the metalloproteinase gene expression of tumor invasively involving matrix metalloproteinases (MMP-2 and MMP-9), inhibition of the development of hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF), all these aforementioned factors being closely related to the formation of a new blood vessel [50].