This protein is overexpressed in the first stage of life of the parasite and the chemical inhibition of it leads to the death of the organism, making this DOT1L analog protein a great target for the treatment of the disease Moreover, H3K79me2 increases progressively with aging, suggesting its role in aging; therefore, DOT1L seems to be also an attractive target for diseases associated with aging deregulation, such as Hutchinson-Gilford progeria syndrome [38]. Here, DOT1L is linked to Hutchinson-Gilford progeria syndrome.