AKT1 and neuroblastoma: As an underlying mechanism of donepezil to inhibit Aβ-induced neurotoxicity in SH-SY5Y neuroblastoma cells, other pharmacological properties such as activation of PI3K/Akt and/or Sigma-1 receptor have been proposed: donepezil protected Aβ-induced cytotoxicity through promoting oligodendrocyte differentiation by activating the PI3K/Akt pathway [12,45].