CYP1B1 and liver cancer: In a human hepatocellular carcinoma cell line (HepG2), the expression levels of miR-27b and CYP1B1 protein were significantly negatively correlated, which may be a mode of liver tumor transformation [146] However, after studying FB1 levels in 271 liver cancer patients and 280 normal subjects, some scholars concluded that there is no direct association between FB1 intake and liver cancer [147].