CSF2 and myeloid sarcoma: Many findings indicate a central role of Th1, Th17, Th1–Th17-like, Th22, and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)-producing CD4+T cells, in beginning and prolonging the inflammatory reactions and in causing neurodegeneration in MS as well as dysfunction in regulatory T cell (Treg) subsets [25,26].