ACHE and Alzheimer disease: Despite the efforts devoted to discovering novel disease-modifying pharmacological treatments, only few drugs are available for symptomatic treatment of mild-to-moderate AD, which are the acetylcholinesterase (AChE) reversible (galantamine and donepezil) or pseudo-irreversible (rivastigmine) inhibitors, and the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine.