circNF1–419 interacts with dynamin-1 and adaptor protein 2 B1 (AP2B1), regulating their mRNA splicing, stabilization, and translation, and its overexpression reduces AD marker proteins (Tau, p-Tau, Aβ1–42, and APOE), as well as aging and inflammatory factors such as TNF and the nuclear factor kappa B subunit 1 (NKFB1), indicating delayed senile dementia and progression of AD [211]. Here, APOE is linked to Alzheimer disease.