This is the case for the splicing factors nova alternative splicing regulator 1 (NOVA1), RNA binding fox-1 homolog 1/2 (RBFOX1/2), and KH RNA binding domain containing signal transduction-associated 3 (KHDRBS3); although these are downregulated in both neurodegenerative diseases and aging, they are less expressed in the brains of patients with neurodegenerative diseases than in those from older healthy individuals [41]. This evidence concerns the gene NOVA1 and neurodegenerative disease.