In a previous study investigating the role of XAB2 in HR in the U2OS human osteosarcoma cell line, siRNA-mediated depletion of XAB2 resulted in a decrease in CPT-induced chromatin-bound RPA, as assessed by flow cytometry analysis, which was interpreted as indicative of defective end resection (33). The gene discussed is RPA1; the disease is osteosarcoma.