The blood and tissue levels of TOS and MDA were higher, and the TAS and GSH levels and SOD activity were lower in the S group than in the C group, indicating a disrupted oxidant/antioxidant balance in favor of oxidants and thus oxidative stress, as observed in other inflammatory diseases, such as osteoarthritis and pulmonary fibrosis [39, 40]. This evidence concerns the gene SOD1 and osteoarthritis.