The canonical and noncanonical pathways were thought to be mutually exclusive, but Barquilla and colleagues recently reported that the two can coexist and that the EphA2 canonical signaling can be rewired in prostate cancer cells by androgenic receptors leading to the phosphorylation of S897EphA2 [17], the same key residue important for HHV-8 infection [54]. This evidence concerns the gene EPHA2 and Familial prostate cancer.