TICAM2 and atherosclerosis: With chronic subclinical endotoxemia, TRAM is involved in monocyte inflammatory polarization, at least partially through promoting peroxisome dysfunction and intracellular ROS accumulation, which subsequently activate c-SRC and STATs to alter the phenotype and function of monocytes/macrophages into a proinflammatory state conducive for exacerbated atherosclerosis.