Inflammatory monocytes exhibit elevated CCR2/CCR5/ICAM-1 (murine intermediate Ly6C+; classical Ly6C++ inflammatory monocytes, equivalents of human intermediate CD14+CD16+, classical CD14+CD16– inflammatory monocytes) and are the primary innate cells infiltrating atherosclerotic plaques propagating atherosclerosis (4, 5). The gene discussed is CCR5; the disease is atherosclerosis.