Interestingly, several laboratories have shown that hyperactive mTORC1 contributes to tau pathology (e.g. neurofibrillary tangles), which in addition to amyloid plaques, is a classic hallmark of AD (An et al., 2003; Caccamo et al., 2013; Khurana et al., 2006). The gene discussed is MAPT; the disease is Alzheimer disease.