It has been postulated that initial impairments to proteostasis pathways promote the accumulation and aggregation of misfolded proteins observed in neurodegenerative disorders, including the accumulation of the aggregation‐prone Aβ and tau, whose plaque deposition and tangle formation, respectively, are considered the hallmarks of AD (Balch et al., 2008; Chiti & Dobson, 2017; Hipp et al., 2014; Klaips et al., 2018; Kundra et al., 2017). Here, MAPT is linked to Alzheimer disease.