A multivariable Cox-regression model was performed for the prediction of thromboembolic events including the potential cancer-associated risk factors: intrahepatic vs. extrahepatic CC, stage IV disease, vascular or lymphatic compression, Khorana score > 2 and ONKOTEV score ≥ 2, the blood biomarkers CRP > upper limit of normal (ULN) and serum bilirubin > ULN and the baseline risk factors: age and BMI as continuous variables, history of TE and pre-existing anticoagulation with VKA or DOAC. This evidence concerns the gene CRP and cholangiocarcinoma.