RB1 and nonpapillary renal cell carcinoma: Even though, additional inactivation of the retinoblastoma gene (Rb) is able to induce ccRCC like tumors in VHLΔ/Δ,Tp53Δ/Δ,RbΔ/Δ mice, these tumors do not demonstrate metastatic potential (Giacomelli et al. 2018; Harlander et al. 2017).