Albers et al. found that combined inactivation of the von Hippel Lindau (VHL) gene and Tp53 induces simple cysts which have some precursor features of ccRCC but inactivation of VHL and p53 was not sufficient enough to induce ccRCC development (Albers et al. 2013). This evidence concerns the gene TP53 and nonpapillary renal cell carcinoma.