According to the expression of these nine lncRNAs for the overall survival prediction of RCC patients with stage IV and histological grade of G4, we established a risk score of the 9-lncRNA signature with the following formula: Risk score = (KIAA2012-AS1 × 95.28813027) + (CCNT2-AS1 × 2.637995925)+ (ITPKB-AS1×-51.44559677)+ (TBX2-AS1 × 1.102500797)+ (NUTM2A-AS1 × 3.340712729)+ (LINC02522 × 7.500647683)+ (LINC02384×-0.515463704)+ (LINC01559×-0.284528539)+ (LINC00865 × 2.265026437). The gene discussed is ITPKB; the disease is renal cell carcinoma.