Reportedly, miR-1281 has tumor-suppressive properties in certain types of cancer; specifically, in osteosarcoma, miR-1281 expression is modulated by p53, and it is upregulated under endoplasmic reticulum stress, which promotes the apoptosis of cancer cells by negatively regulating ubiquitin-specific peptidase 39 (17). The gene discussed is USP39; the disease is osteosarcoma.