Reportedly, miR-1281 has tumor-suppressive properties in certain types of cancer; specifically, in osteosarcoma, miR-1281 expression is modulated by p53, and it is upregulated under endoplasmic reticulum stress, which promotes the apoptosis of cancer cells by negatively regulating ubiquitin-specific peptidase 39 (17). This evidence concerns the gene USP39 and neoplasm.