Previous studies have indicated that females who had FMR1 premutation with or without FXTAS exhibited higher incidences of immune-mediated disorders, such as autoimmune thyroid disease, fibromyalgia, irritable bowel syndrome, rheumatoid arthritis, systemic lupus erythematous, and multiple sclerosis, than age-matched controls [21, 25–28]. Here, FMR1 is linked to rheumatoid arthritis.