PPY and Hyperglycemia: However, the induction of hyperglycaemia by the administration of DT to 6-week-old male Ppy-Cre;Rosa26-YFP;Ins-TR1 mice, in which beta cells can be ablated by the administration of DT acting on the DT receptors that they express, did not change the proportion of Ppy-lineage beta cells among the remaining beta cells 7 days after DT administration (Fig. 6c,d).