TG and hypothyroidism: In addition, PO was therapeutically recommended in a previous study in hypothyroidism mice model via its elevating effect on thyroid hormones and the histopathological evidenced recovery of thyroid parenchyma [64] as regards the effect of thyroid hormones on different cell types in the testes, such as the Leydig cells, Sertoli cells, and germ cells, with T3 regulating testicular growth and maturation [65].