Induction of diabetes in G2 significantly increased the levels of the examined liver function enzymes (ALT, γ-GT, and ALP) compared with the negative control, although treating the diabetic rats in G3, G4, G5, and G6 with the aqueous extracts of leaves and seeds of fenugreek and buckthorn significantly (P < 0.001) decreased the elevated liver function enzyme action. This evidence concerns the gene GPT and diabetes mellitus.