Therefore, this study is aimed at assessing the correlation between FRAX scores for the estimated 10-year risk of a major and hip osteoporotic fractures and the serum levels of sRANKL, OPG, sRANKL/(OPG) ratio, Dickkopf-1 (DKK-1), and sclerostin (SOST) in RA patients. The gene discussed is TNFRSF11B; the disease is rheumatoid arthritis.