Since inflammation is one of the important pathological mechanisms of hypoxia injury, curcumin may inhibit the activation of caspase-1 by inhibiting NLRP3 inflammasome, thereby reducing the maturation and release of IL-1, reducing the proliferation of inflammation-induced PASMCs, improving the remodeling of blood vessels, and ultimately reducing pulmonary artery pressure in PHA rats. The gene discussed is CASP1; the disease is Pelger-Huet anomaly.