PCSK1 and familial dilated cardiomyopathy: Strikingly, we observed that in the Nec-1 group, cardiac conditions were improved, inflammatory infiltration was ameliorated, myocardial cell injury was attenuated, and, thus, most of the pathological lesions of DCM in Nec-1 group were alleviated compared to the EAM-DMSO group (Figures 4, 8A–F).