With scatterplots, the relationship between S100A8 and CTSL genes and SARS-CoV-2 infection was suggested to be only negatively related to viral gene expression levels in high infections, and all COVID-19–related viral genes, especially N and ORF1ab genes, showed a positive relationship (Figure 2D and Supplementary Figures 4A,B). The gene discussed is S100A8; the disease is COVID-19.