The role of BER in cancer drug resistance had been proposed by many studies (Horton et al., 1995; Faivre et al., 2003; Preston et al., 2009; Yang et al., 2010; Sawant et al., 2017), and PARP1 plays an important role in the BER pathway (Ronson et al., 2018). Here, PARP1 is linked to cancer.