Interestingly, in the current study, through a complete research on the published single-cell RNA-sequencing (scRNA-seq) databases, by comparative analysis of normal mouse breast epithelial cell and TNBC cancer cells in mouse models, as well human primary and brain metastatic TNBC at single cell levels, we revealed that RPL15 was significantly increased in mouse tumor cells and metastatic TNBC compared to corresponding controls. This evidence concerns the gene RPL15 and neoplasm.