PRKN and Parkinson disease: As a well-established causative gene in PD, the interactions between SNCA and other PD-related genes, such as LRRK2, Parkin RBRE3 ubiquitin protein ligase (PRKN), Parkinsonism-associated deglycase (PARK7), PTEN-induced putative kinase 1 (PINK1), and ATPase 13A2 (ATP13A2), have been extensively studied (Bekris et al., 2010; Nuytemans et al., 2010; Klein and Westenberger, 2012; Heman-Ackah et al., 2013).