After adjusting the risk factors (GA, BW, 1- and 5-min Apgar scores, history of abnormal pregnancy, fetal distress, IUGR, use of surfactants, HsPDA, early PH, MV time, respiratory support pattern) determined by univariate analysis, the NT-proBNP level on the 7th day (±2 days) was still an important predictor of moderate-to-severe BPD/death (OR = 3.152; 95%CI: 2.347~4.234; P < 0.001; Table 4). The gene discussed is NPPB; the disease is bronchopulmonary dysplasia.