GZMB and neoplasm: B-cells role can be summarized as 1) sampling local tumor antigens for presentation, 2) maturation to plasma cells and production of antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC), 3) promote antitumor immunity by secreting IFN-γ and IL-12 as well as Granzyme B and TRAIL, which directly kill tumor cells (50).